Rosetta MCP Server v1.3.1

by Ariel J. Ben-Sasson (molCore) — for the RosettaCommons community & any bio-engineers out there

Give your AI coding agent expert-level knowledge of protein modeling and design. Ask naive questions, get working code, translate and validate across Rosetta, PyRosetta, and Biotite.

This is a Model Context Protocol server providing 10 remote tools and 9 additional local tools.

Connect your AI agent

Claude.ai: Settings → Connectors → Add → https://mcp.molcore.bio/mcp

Full local install (with scoring & protocols): npm install -g rosetta-mcp-server

Available remotely

get_rosetta_info
get_rosetta_help
validate_xml
xml_to_pyrosetta
rosetta_to_biotite
biotite_to_rosetta
translate_rosetta_script_to_biotite
search_rosetta_web_docs
get_rosetta_web_doc
get_local_setup
sets up locally

Requires local install

npm install -g rosetta-mcp-server

These tools need PyRosetta or the Rosetta binary on your machine.

pyrosetta_score
pyrosetta_introspect
run_rosetta_scripts
rosetta_scripts_schema
check_pyrosetta
install_pyrosetta_installer
find_rosetta_scripts
get_cached_docs
python_env_info

Links